Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses.

@article{Huo2012TargetedOO,
  title={Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses.},
  author={Yuqing Huo and Xin Yong Guo and Honggui Li and Hang Xu and Vera Halim and Weiyu Zhang and Huan Wang and Yang-Yi Fan and Kuok Teong Ong and S O Woo and Robert S. Chapkin and Douglas G Mashek and Yanming Chen and Hui Dong and Fuer Lu and Lai Wei and Chaodong Wu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 25},
  pages={21492-500}
}
Increasing evidence demonstrates the dissociation of fat deposition, the inflammatory response, and insulin resistance in the development of obesity-related metabolic diseases. As a regulatory enzyme of glycolysis, inducible 6-phosphofructo-2-kinase (iPFK2, encoded by PFKFB3) protects against diet-induced adipose tissue inflammatory response and systemic insulin resistance independently of adiposity. Using aP2-PFKFB3 transgenic (Tg) mice, we explored the ability of targeted adipocyte PFKFB3… CONTINUE READING
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Adipocyte iPFK2 Dissociates Inflammation from Fat Deposition

  • V. T. Samuel, Z. X. Liu, +4 authors Romanelli
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