Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer.

@article{Nikiforova2013TargetedNS,
  title={Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer.},
  author={Marina N. Nikiforova and Abigail I. Wald and Somak Roy and Mary Beth Durso and Yuri E Nikiforov},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 11},
  pages={E1852-60}
}
OBJECTIVES Next-generation sequencing (NGS) allows for high-throughput sequencing analysis of large regions of the human genome. We explored the use of targeted NGS for simultaneous testing for multiple mutations in thyroid cancer. DESIGN A custom panel (ThyroSeq) was designed to target 12 cancer genes with 284 mutational hot spots. Sequencing was performed to analyze DNA from 228 thyroid neoplastic and nonneoplastic samples including 105 frozen, 72 formalin-fixed, and 51 fine-needle… CONTINUE READING
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