Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study.

@article{Iacono2015TargetedNS,
  title={Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study.},
  author={Marco Lo Iacono and Valentina Monica and Luisella Righi and Federica Del Grosso and Roberta Libener and Simona Vatrano and Paolo Bironzo and Silvia Novello and Loredana Musmeci and Marco Volante and Mauro Papotti and Giorgio V Scagliotti},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2015},
  volume={10 3},
  pages={492-9}
}
INTRODUCTION Malignant pleural mesothelioma (MPM) is a rare malignant disease, and the understanding of molecular pathogenesis has lagged behind other malignancies. METHODS A series of 123 formalin-fixed, paraffin-embedded tissue samples with clinical annotations were retrospectively tested with a commercial library kit (Ion AmpliSeq Cancer Hotspot Panel v.2, Life Technologies, Grand Island, NY) to investigate 50 genes plus other two, BRCA1-associated protein-1 (BAP-1) and neurofibromatosis-2… CONTINUE READING
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