Targeted neuronal gene expression and longevity in Drosophila.

@article{Phillips2000TargetedNG,
  title={Targeted neuronal gene expression and longevity in Drosophila.},
  author={J. P. Phillips and Tony L. Parkes and Arthur J. Hilliker},
  journal={Experimental gerontology},
  year={2000},
  volume={35 9-10},
  pages={1157-64}
}
Earlier studies from this laboratory have shown that in the insect, Drosophila melanogaster, the motorneuron is an important cellular nexus between the metabolism of reactive oxygen species (ROS) and adult lifespan. This was demonstrated by experiments in which expression of CuZn SOD (SOD1) specifically in motorneurons was shown to extend the mean and maximum adult lifespans to 140% of normal, and to rescue the majority of deliterious phenotypes displayed by SOD1-null mutants. We have… CONTINUE READING

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