Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

@article{Fredman2015TargetedNC,
  title={Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice},
  author={Gabrielle Fredman and Nazila Kamaly and Stefano Spolitu and Jaclyn Milton and Devram Sampat Ghorpade and Raymond Chiasson and George Kuriakose and Mauro Perretti and Omid C Farokhzad and Ira Tabas},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={275ra20-275ra20}
}
Chronic, nonresolving inflammation is a critical factor in the clinical progression of advanced atherosclerotic lesions. In the normal inflammatory response, resolution is mediated by several agonists, among which is the glucocorticoid-regulated protein called annexin A1. The proresolving actions of annexin A1, which are mediated through its receptor N-formyl peptide receptor 2 (FPR2/ALX), can be mimicked by an amino-terminal peptide encompassing amino acids 2–26 (Ac2-26). Collagen IV (Col IV… CONTINUE READING
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Nanoparticle

  • A. Seth, N. Wibowo, C. X. Zhao, N. Mitter, C. Yu, A. P. Middelberg
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