Targeted mutagenesis of the P22 portal protein reveals the mechanism of signal transmission during DNA packaging.

The portal vertex in dsDNA bacteriophage serves as the site for genome encapsidation and release. In several of these viruses, efficient termination of DNA packaging has been shown to be dependent on the density of packaged DNA. The portal protein has been implicated as being part of the sensor that regulates packaging termination through DNA-dependent… CONTINUE READING