Targeted mutagenesis in zebrafish

  title={Targeted mutagenesis in zebrafish},
  author={Ian G. Woods and Alexander F Schier},
  journal={Nature Biotechnology},
VOLUME 26 NUMBER 6 JUNE 2008 NATURE BIOTECHNOLOGY sequence could be detected in a test genome. Given its high throughput, shotgun-SBH could work well as a resequencing platform for the discovery of single nucleotide polymorphisms or mutations in coding and noncoding exons, which represent nearly 2% of the human genome (55 megabases) and can be harvested using exon-capture technologies7,8. How does shotgun-SBH compare with other DNA sequencing platforms? Whereas other platforms require… CONTINUE READING
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