Targeted mutagenesis in pathogenic Leptospira species: disruption of the LigB gene does not affect virulence in animal models of leptospirosis.

@article{Croda2008TargetedMI,
  title={Targeted mutagenesis in pathogenic Leptospira species: disruption of the LigB gene does not affect virulence in animal models of leptospirosis.},
  author={Julio Croda and Cl{\'a}udio Pereira Figueira and Elsio A Wunder and Cleiton Silva Santos and Mitermayer G Reis and Albert I Ko and Mathieu Picardeau},
  journal={Infection and immunity},
  year={2008},
  volume={76 12},
  pages={
          5826-33
        }
}
The pathogenic mechanisms of Leptospira interrogans, the causal agent of leptospirosis, remain largely unknown. This is mainly due to the lack of tools for genetically manipulating pathogenic Leptospira species. Thus, homologous recombination between introduced DNA and the corresponding chromosomal locus has never been demonstrated for this pathogen. Leptospiral immunoglobulin-like repeat (Lig) proteins were previously identified as putative Leptospira virulence factors. In this study, a ligB… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Similar Papers

Loading similar papers…