Targeted mutagenesis and genetic analysis of a Drosophila receptor-linked protein tyrosine phosphatase gene

@article{Hamilton1995TargetedMA,
  title={Targeted mutagenesis and genetic analysis of a Drosophila receptor-linked protein tyrosine phosphatase gene},
  author={Bruce A Hamilton and Alan Yu Ho and Kai Zinn},
  journal={Roux's archives of developmental biology},
  year={1995},
  volume={204},
  pages={187-192}
}
Several Drosophila receptor-linked protein tyrosine phosphatases (R-PTPs) are selectively expressed on axons of the developing embryonic central nervous system. The extracellular domains of these axonal R-PTPs are homologous to neural adhesion molecules. Thus, R-PTPs may directly couple cell recognition to signal transduction via control of tyrosine phosphorylation. To examine the function of these molecules during nervous system development, we wished to generate mutations in R-PTP genes. It… CONTINUE READING
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