Targeted molecular therapy of anaplastic thyroid carcinoma with AEE788.

@article{Kim2005TargetedMT,
  title={Targeted molecular therapy of anaplastic thyroid carcinoma with AEE788.},
  author={Seungwon W Kim and Bradley A. Schiff and Orhan Gazi Yiğitbaşi and Dao D Doan and Samar A. Jasser and Benjamin Nebiyou Bekele and Mahitosh Mandal and Jeffrey N. Myers},
  journal={Molecular cancer therapeutics},
  year={2005},
  volume={4 4},
  pages={
          632-40
        }
}
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies with a mean survival of only 6 months. The poor prognosis of patients with ATC reflects the current lack of curative therapeutic options and the need for development of novel therapeutic strategies. In this study, we report the results of a preclinical study of AEE788, a dual inhibitor of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, against ATC… CONTINUE READING
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