Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges.

@article{Reardon2014TargetedMT,
  title={Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges.},
  author={David A Reardon and Patrick Yung Chih Wen and Ingo K. Mellinghoff},
  journal={Neuro-oncology},
  year={2014},
  volume={16 Suppl 8},
  pages={viii7-13}
}
Epidermal growth factor receptor (EGFR) has emerged as a highly attractive therapeutic target in glioblastoma (GBM) based on its high frequency of gene amplification and mutation and its identification as an upstream trigger of dysregulated cell signaling cascades that drive GBM pathophysiology. Extensive investment has been committed in an attempt to exploit EGFR therapeutically to improve outcome for GBM patients, including the development of a variety of EGFR-targeting therapeutics as well… CONTINUE READING

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