Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.

@article{Homanics1993TargetedMO,
  title={Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.},
  author={Gregg E Homanics and T. Jarrod Smith and Shu Hua Zhang and Dong-ki Lee and Stephen G. Young and Nobuyo Maeda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 6},
  pages={
          2389-93
        }
}
Familial hypobetalipoproteinemia is an autosomal codominant disorder resulting in a dramatic reduction in plasma concentrations of apolipoprotein (apo) B, cholesterol, and beta-migrating lipoproteins. A benefit of hypobetalipoproteinemia is that mildly affected individuals may be protected from coronary vascular disease. We have used gene targeting to generate mice with a modified Apob allele. Mice containing this allele display all of the hallmarks of human hypobetalipoproteinemia: they… CONTINUE READING

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