Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

@article{Morgan1992TargetedMO,
  title={Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations},
  author={Bruce A. Morgan and Juan -Carlos Izpis{\'u}a-Belmonte and Denis Duboule and Clifford J Tabin},
  journal={Nature},
  year={1992},
  volume={358},
  pages={236-239}
}
IN the limb bud the 5' members of the Hox-4 gene cluster are expressed in a nested set of overlapping domains which are progressively restricted in the posterior and distal directions1. These domains arise early in limb bud development and come to approximate the primordia of the major structural elements of the limb along the anterior/posterior axis2 (Fig. 1). This pattern, and the fact that surgical manipulations which lead to mirror image duplications along the anterior/posterior axis give… CONTINUE READING
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