Targeted minimum loss based estimation of causal effects of multiple time point interventions.

  title={Targeted minimum loss based estimation of causal effects of multiple time point interventions.},
  author={Mark J. van der Laan and Susan Gruber},
  journal={The international journal of biostatistics},
  volume={8 1}
We consider estimation of the effect of a multiple time point intervention on an outcome of interest, where the intervention nodes are subject to time-dependent confounding by intermediate covariates. In previous work van der Laan (2010) and Stitelman and van der Laan (2011a) developed and implemented a closed form targeted maximum likelihood estimator (TMLE) relying on the log-likelihood loss function, and demonstrated important gains relative to inverse probability of treatment weighted… CONTINUE READING

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