Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells.

@article{Teng2011TargetedMO,
  title={Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells.},
  author={I-Wen Teng and Pei-Chi Hou and Kyu Sang Lee and P G Chu and K L Yeh and Victor X. Jin and Min-Jen Tseng and Shaw-Jenq Tsai and Yu-sun Chang and Chi-Sheng Wu and Hsiao Fang Sunny Sun and Kuen-daw Tsai and L M Jeng and Kenneth P. Nephew and Tim Hui-Ming Huang and Shu-Huei Hsiao and Y. C. Leu},
  journal={Cancer research},
  year={2011},
  volume={71 13},
  pages={4653-63}
}
Although DNA hypermethylation within promoter CpG islands is highly correlated with tumorigenesis, it has not been established whether DNA hypermethylation within a specific tumor suppressor gene (TSG) is sufficient to fully transform a somatic stem cell. In this study, we addressed this question using a novel targeted DNA methylation technique to methylate the promoters of HIC1 and RassF1A, two well-established TSGs, along with a two-component reporter system to visualize successful targeting… CONTINUE READING

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