Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles.

@article{Liao2011TargetedMP,
  title={Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles.},
  author={Gary J. W. Liao and Fiona F. M. Lun and Yama W. L. Zheng and K. C. Allen Chan and Tak Yeung Leung and Tze Kin Lau and Rossa W. K. Chiu and Yuk Ming Dennis Lo},
  journal={Clinical chemistry},
  year={2011},
  volume={57 1},
  pages={92-101}
}
BACKGROUND Massively parallel sequencing has recently been used in noninvasive prenatal diagnosis. The current costs of this technology are still relatively expensive, however, and sample throughput is still relatively low when it is used as a molecular diagnostic tool. Rather than nonselectively sequencing the genome, target enrichment provides a logical approach for more efficient and cost-effective massively parallel sequencing because it increases the proportion of informative data from the… CONTINUE READING
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