Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.

@article{Wang2009TargetedLA,
  title={Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.},
  author={Yuqin Wang and K. Sousa and K. Bodin and S. Theofilopoulos and P. Sacchetti and M. Hornshaw and G. Woffendin and K. Karu and J. Sjövall and E. Arenas and W. Griffiths},
  journal={Molecular bioSystems},
  year={2009},
  volume={5 5},
  pages={
          529-41
        }
}
In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC)-mass spectrometry (MS) and tandem mass spectrometry (MS(n)) low levels of oxysterols (estimated 2-165 ng g(-1) wet weight) were identified in cortex (Ctx) and spinal cord (Sc). The identified oxysterols include 7 alpha-, 7 beta-, 22R-, 24S-, 25- and 27-hydroxycholesterol; 24,25- and 24,27… Expand
36 Citations
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS[S]
  • 41
  • PDF
Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?*
  • 101
  • PDF
Explorer 24 S , 25-Epoxycholesterol in mouse and rat brain
  • PDF
Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation.
  • 37
Analysis of oxysterol metabolomes.
  • W. Griffiths, Yuqin Wang
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 2011
  • 37
Analytical strategies for characterization of oxysterol lipidomes: liver X receptor ligands in plasma.
  • 51
  • PDF
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
  • 12
  • PDF
New methods for analysis of oxysterols and related compounds by LC–MS
  • 37
  • PDF
Analysis of neurosterols by GC-MS and LC-MS/MS.
  • W. Griffiths, Yuqin Wang
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2009
  • 58
...
1
2
3
4
...

References

SHOWING 1-10 OF 76 REFERENCES
Analysis of neurosterols and neurosteroids by mass spectrometry.
  • 35
Transport of side-chain oxidized oxysterols in the human circulation.
  • 122
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
  • 58
Discovering oxysterols in plasma: a window on the metabolome.
  • 67
Neurosteroid Hydroxylase CYP7B
  • 75
  • PDF
...
1
2
3
4
5
...