• DOI:10.1039/b819502a
Corpus ID: 5297168

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.

@article{Wang2009TargetedLA,
  title={Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.},
  author={Yuqin Wang and K. Sousa and K. Bodin and S. Theofilopoulos and P. Sacchetti and M. Hornshaw and G. Woffendin and K. Karu and J. Sjövall and E. Arenas and W. Griffiths},
  journal={Molecular bioSystems},
  year={2009},
  volume={5 5},
  pages={
          529-41
        }
}

• Yuqin Wang, K. Sousa, +8 authors W. Griffiths
• Published 2009
• Chemistry, Medicine
• Molecular bioSystems

In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC)-mass spectrometry (MS) and tandem mass spectrometry (MS(n)) low levels of oxysterols (estimated 2-165 ng g(-1) wet weight) were identified in cortex (Ctx) and spinal cord (Sc). The identified oxysterols include 7 alpha-, 7 beta-, 22R-, 24S-, 25- and 27-hydroxycholesterol; 24,25- and 24,27… Expand

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