Targeted learning ensembles for optimal individualized treatment rules with time-to-event outcomes.

@article{Daz2018TargetedLE,
  title={Targeted learning ensembles for optimal individualized treatment rules with time-to-event outcomes.},
  author={Iv{\'a}n D{\'i}az and O. A. Savenkov and Karla V. Ballman},
  journal={Biometrika},
  year={2018},
  volume={105 3},
  pages={
          723-738
        }
}
  • Iván Díaz, O. A. Savenkov, Karla V. Ballman
  • Published 2018
  • Mathematics, Medicine
  • Biometrika
  • We consider estimation of an optimal individualized treatment rule when a high-dimensional vector of baseline variables is available. Our optimality criterion is with respect to delaying the expected time to occurrence of an event of interest. We use semiparametric efficiency theory to construct estimators with properties such as double robustness. We propose two estimators of the optimal rule, which arise from considering two loss functions aimed at directly estimating the conditional… CONTINUE READING

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