• Corpus ID: 248862932

Targeted learning: Towards a future informed by real-world evidence

@inproceedings{Gruber2022TargetedLT,
  title={Targeted learning: Towards a future informed by real-world evidence},
  author={Susan Gruber and Rachael V. Phillips and Hana Lee and Martin Ho and John Concato and Mark J. van der Laan},
  year={2022}
}
The 21st Century Cures Act of 2016 includes a provision for the U.S. Food and Drug Administration (FDA) to evaluate the potential use of real-world evidence (RWE) to support new indications for use for previously approved drugs, and to satisfy post-approval study requirements. Extracting reliable evidence from real-world data (RWD) is often complicated by a lack of treatment randomization, potential intercurrent events, and informative loss to follow up. Targeted Learning (TL) is a sub-field of… 

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