Targeted inhibition of tumour cell growth by a bispecific single-chain toxin containing an antibody domain and TGF alpha.

@article{Schmidt1996TargetedIO,
  title={Targeted inhibition of tumour cell growth by a bispecific single-chain toxin containing an antibody domain and TGF alpha.},
  author={Melanie Schmidt and Winfried S. Wels},
  journal={British Journal of Cancer},
  year={1996},
  volume={74},
  pages={853 - 862}
}
Overexpression of the epidermal growth factor receptor (EGFR) and ErbB-2 has been observed in a variety of human tumours, making these receptors promising targets for directed tumour therapy. Since many tumour cells express both ErbB-2 and EGFR and these receptors synergise in cellular transformation, therapeutic reagents simultaneously binding to ErbB-2 and EGFR might offer advantages for tumour therapy. We have previously described the potent anti-tumoral activity of a bispecific antibody… CONTINUE READING
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Activity of a recombinant fusion protein between transforming growth factor type 2 and Pseudomonas toxin

  • VK CHAUDHARY, DJ FITZGERALD, I ADHYASANDPASTAN
  • Proc . Nail Acad . Sci . USA
  • 1987
Highly Influential
14 Excerpts

The biology of erbB2 / neu / HER - 2 and its role in cancer

  • DF HYNESNEANDSTERN
  • Biochim . Biophys . Acta
  • 1994

Heregulin induces tyrosine phosphorylation of HER 4 / pI 80 bB 4

  • GD PLOWMAN, JM GREEN, JM CULOUSCOU, GW CARLTON, S ROTHWELLVMANDBUCKLEY
  • Nature
  • 1993

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