Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins.

  title={Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins.},
  author={M Jeschke and Winfried S. Wels and Wilhelm Dengler and Roland Imber and Elisabeth Stoecklin and Bernd Groner},
  journal={International journal of cancer},
  volume={60 5},
Fusion of functional domains of proteins by in vitro recombination of gene fragments can be used to generate novel anti-tumor agents. The combination of tumor-cell-recognition functions and toxic functions results in cytotoxic molecules with a high specificity for tumor cells. Human adenocarcinomas are frequently characterized by over-expression of members of the epidermal-growth-factor (EGF) receptor family (ErbB-1, 2, 3 and 4), when compared with normal cells. These tumors are particularly… CONTINUE READING


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