Targeted inhibition of platelet-derived growth factor receptor-β subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats

@article{Chen2008TargetedIO,
  title={Targeted inhibition of platelet-derived growth factor receptor-β subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats},
  author={S Chen and Y-x Chen and X-R Zhang and Haining Qian and W-Z Chen and W-f Xie},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={1424-1435}
}
The activation of hepatic stellate cells (HSCs) is the key event of the pathogenesis of hepatic fibrosis. Platelet-derived growth factor (PDGF) is the most potent mitogen for HSCs, and PDGF receptor-β subunit (PDGFR-β) is required for the proliferation of HSCs induced by PDGF. In this study, a high gene-silencing-efficacy PDGFR-β small interference RNA (siRNA) was synthesized that could suppress the PDGFR-β expression and inhibit the activation and proliferation but could not induce the… CONTINUE READING

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