Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer.

@article{Gulhati2009TargetedIO,
  title={Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer.},
  author={Pat Gulhati and Qingsong Cai and Jing Li and Jianyu Liu and Piotr G. Rychahou and Suimin Qiu and Eun Youb Lee and Scott R. Silva and Kanika A. Bowen and Tianyan Gao and Bernard Mark Evers},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 23},
  pages={7207-16}
}
PURPOSE The mammalian target of rapamycin (mTOR) kinase acts downstream of phosphoinositide 3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because approximately 60% of sporadic colorectal cancers (CRC) exhibit high levels of activated Akt, we determined whether downstream mTOR signaling pathway components are overexpressed and activated in CRCs. EXPERIMENTAL DESIGN HCT116, KM20, Caco-2, and SW480 human CRC cells were used to determine the effects of pharmacologic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Hypothesis: cell signalling influences age-related risk of colorectal cancer

Journal of cellular and molecular medicine • 2015
View 5 Excerpts
Highly Influenced

Ketogenesis contributes to intestinal cell differentiation

Cell Death and Differentiation • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Defining the role of mTOR in cancer.

Cancer cell • 2007
View 11 Excerpts
Highly Influenced

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 10 Excerpts
Highly Influenced

Molecular mechanisms of mTOR-mediated translational control

Nature Reviews Molecular Cell Biology • 2009
View 1 Excerpt

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…