Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function.

@article{Hill2002TargetedIO,
  title={Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function.},
  author={Joseph A Hill and Beverly A. Rothermel and Ki-dong Yoo and Barry M Cabuay and Elaine M. Demetroulis and Robert M. Weiss and William Kutschke and Rhonda Bassel-Duby and R. Sanders Williams},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 12},
  pages={10251-5}
}
Calcineurin is a Ca(2+)/calmodulin-activated protein phosphatase that transduces hypertrophic stimuli to regulate transcriptional control of myocyte transformation. It is not known whether overexpression of MCIP1, a recently described endogenous inhibitor of calcineurin, impacts the hypertrophic response to pathophysiologically relevant pressure overload. Further, the functional consequences of calcineurin inhibition by MCIP1 under conditions of hemodynamic stress are unknown. Transgenic mice… CONTINUE READING
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Ventricular Function with MCIP1-attenuated Hypertrophy 10255 by gest on O cber 28

  • Robert M. Weiss, William Kutschke, +4 authors Elaine
  • January 10,
  • 2002

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