Targeted inhibition of Stat 3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

@inproceedings{Leong2003TargetedIO,
  title={Targeted inhibition of Stat 3 with a decoy oligonucleotide abrogates head and neck cancer cell growth},
  author={P L Stanley Leong and Genevieve A. Andrews and Daniel Ezra Johnson and Kevin F. Dyer and Sichuan Xi and Jeffrey C. Mai and P. David Robbins and Seshu Gadiparthi and Nancy A. Burke and Simon Watkins and Jennifer R Grandis},
  year={2003}
}
The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck (SCCHN). Previous investigations have demonstrated that activated Stat3 contributes to a loss of growth control and transformation. To investigate the therapeutic potential of blocking Stat3 in cancer cells, we developed a transcription factor decoy to selectively abrogate activated Stat3. The Stat3 decoy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…