Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137.

@article{Zhao2017TargetedIO,
  title={Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137.},
  author={Gang Zhao and Guoliang Wang and Hongmin Bai and Tiandong Li and Fanghe Gong and Huan Yang and Jinchong Wen and Weimin Wang},
  journal={European journal of pharmacology},
  year={2017},
  volume={802},
  pages={
          20-26
        }
}
Histone deacetylases (HDACs) have been suggested to be potential therapeutic targets for cancer treatment. Recent studies revealed that HDAC8 expression was associated with poor prognostic markers and poor overall survival rate of neuroblastoma (NB). Our present study revealed that among the four members of class I HDACs, HDAC8 is significantly over expressed in NB cells as compared with the normal fibroblast 3T3 cells or primary normal human astrocytes (NHA) cells. Targeted inhibition of HDAC8… CONTINUE READING
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