Targeted infusions of supradose Cisplatin with systemic neutralization for carcinomas invading the temporal bone.

@article{Robbins1996TargetedIO,
  title={Targeted infusions of supradose Cisplatin with systemic neutralization for carcinomas invading the temporal bone.},
  author={Kevin Thomas Robbins and P K Pelliteri and Daniel Vicario and Charles W. Kerber and J. Hinton Robertson and Catherine Hanchett and Stephen B. Howell},
  journal={Skull base surgery},
  year={1996},
  volume={6 2},
  pages={
          69-76
        }
}
In an attempt to improve the dismal prognosis for patients with advanced cancer involving the temporal bone, a regional chemotherapy technique was piloted as part of the multimodality therapy for such patients. Rapid supradose cisplatin infusions selectively delivered to the lesion were given to 14 patients with carcinoma involving the temporal bone. Concurrent systemic cisplatin neutralization was achieved with sodium thiosulfate which permitted the use of cisplatin dose intensity regimens… CONTINUE READING