Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.

@article{Knobeloch2000TargetedIO,
  title={Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.},
  author={Klaus-Peter Knobeloch and Mark D Wright and Adrian F Ochsenbein and Oliver Liesenfeld and J{\"u}rgen Loehler and Rolf Martin Zinkernagel and Ivan Horak and Zane Orinska},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 15},
  pages={5363-9}
}
CD37 is a membrane protein of the tetraspanin superfamily, which includes CD9, CD53, CD63, CD81, and CD82. Many of these molecules are expressed on leukocytes and have been implicated in signal transduction, cell-cell interactions, and cellular activation and development. We generated and analyzed mice deficient for CD37. Despite the high expression of CD37 on cells of the immune system, no changes in development and cellular composition of lymphoid organs were observed in mice lacking CD37… CONTINUE READING
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