Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice.

@article{Kundu1998TargetedIO,
  title={Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice.},
  author={Ramendra K. Kundu and Frank O. Sangiorgi and Lisa Y. Wu and Kotoku Kurachi and W. French Anderson and Robert M Maxson and Erlinda M. Gordon},
  journal={Blood},
  year={1998},
  volume={92 1},
  pages={168-74}
}
Hemophilia B is a leading target for gene therapy because current therapy is not optimal. Hence, a murine model of factor IX (F. IX) deficiency was generated to develop gene therapy strategies for hemophilia B. A targeting vector was created by replacing a 3.2-kb segment of the gene encompassing the catalytic domain with a phosphoglycerokinase promoter-driven neomycin resistant (neor) gene cassette. The transfected embryonic stem cell clones generated chimeric male mice, and germ line… CONTINUE READING

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Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
Seven of 19 affected male mice died of exsanguination after tail snipping , and two affected mice died of umbilical cord bleeding .
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