Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes

@article{Akker1999TargetedIO,
  title={Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes},
  author={Elske van den Akker and Mark Reijnen and Jeroen Korving and Antje Brouwer and Frits Meijlink and Jean Deschamps},
  journal={Mechanisms of Development},
  year={1999},
  volume={89},
  pages={103-114}
}
Hoxb8 mutant mice were generated by inserting the lacZ coding sequence in frame with the first exon of Hoxb8. These mice express a fusion protein with a functional beta-galactosidase activity instead of Hoxb8. Mutant embryos were analyzed for anatomical changes. The results indicate that Hoxb8 is not an indispensable regulator of A-P patterning in the forelimb, unlike suggested by our Hoxb8 gain of function experiments (Charité J, DeGraaff W, Shen S, Deschamps J. Cell 1994;78:589-601). The null… CONTINUE READING
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