Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.

@article{Deane2007TargetedIO,
  title={Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.},
  author={Natasha G. Deane and H Charles Manning and A Coe Foutch and M. Kay Washington and Bruce J. Aronow and Darryl J. Bornhop and Robert J Coffey},
  journal={Molecular cancer research : MCR},
  year={2007},
  volume={5 4},
  pages={341-9}
}
The peripheral benzodiazepine receptor (PBR) is a trans-mitochondrial membrane protein that modulates steroid biosynthesis. Recently, up-regulation and nuclear localization of PBR has been shown to be associated with colon, prostate, and breast cancer. PBR has been targeted by the exogenous synthetic ligand, PK11195, for various purposes including imaging. To capitalize on these observations, we developed a high-throughput, noninvasive, in vivo imaging approach to detect spontaneously arising… CONTINUE READING
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