Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates.

@article{Choi2013TargetedHC,
  title={Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates.},
  author={Yong Seok Choi and Shuyu Hou and Leila H. Choe and Kelvin H. Lee},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2013},
  volume={930},
  pages={
          129-35
        }
}
There is significant interest in the development of methods to validate novel biomarkers for Alzheimer's disease (AD) diagnosis. Previously, a proteomic panel of cerebrospinal fluid (CSF) biomarker candidates that differentiated AD and non-AD CSF with accuracy higher than 90% was found; information about these CSF proteins can be used to develop multiple reaction monitoring (MRM) based analytical assays, which offer the possibility of quantifying protein expression level changes in samples, as… CONTINUE READING
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