Targeted genome modification via triple helix formation.

  title={Targeted genome modification via triple helix formation.},
  author={Jennifer M Kalish and Peter M. Glazer},
  journal={Annals of the New York Academy of Sciences},
Triplex-forming oligonucleotides (TFOs) that can bind to duplex DNA in a sequence-specific manner are potential tools to achieve targeted gene modification. Initial studies demonstrated the ability of TFOs to deliver mutagenic agents in a DNA site-specific manner. It has also been found that TFOs can induce gene modification in chromosomal DNA via the effect of the triple helix itself. Gene modification with TFOs includes induced recombination between a DNA target and a donor DNA molecule, a… CONTINUE READING

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