Targeted genome editing tools for disease modeling and gene therapy.

@article{Cai2014TargetedGE,
  title={Targeted genome editing tools for disease modeling and gene therapy.},
  author={Mi Cai and Yi Yang},
  journal={Current gene therapy},
  year={2014},
  volume={14 1},
  pages={
          2-9
        }
}
The development of custom-designed nucleases (CDNs), including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), has made it possible to perform precise genetic engineering in many cell types and species. More recently, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system has been successfully employed for genome editing. These RNA-guided DNA endonucleases are shown to be more efficient and flexible than CDNs… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…