Targeted genome editing in primate embryos

@article{Guo2015TargetedGE,
  title={Targeted genome editing in primate embryos},
  author={Xiangyu Guo and Xiao-Jiang Li},
  journal={Cell Research},
  year={2015},
  volume={25},
  pages={767-768}
}
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases. 

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