Targeted genome editing across species using ZFNs and TALENs.

  title={Targeted genome editing across species using ZFNs and TALENs.},
  author={A. Joseph Wood and Te-Wen Lo and Bryan Zeitler and Catherine S. Pickle and Edward J. Ralston and Andrew H Lee and Rainier Amora and Jeffrey C. Miller and Elo Leung and Xiangdong Meng and Lei Zhang and Edward J. Rebar and Philip D. Gregory and Fyodor D. Urnov and Barbara J Meyer},
  volume={333 6040},
Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species. 
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