Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.

@article{Harris1999TargetedGD,
  title={Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.},
  author={Zena Leah Harris and Alison Durley and Toni K. Man and Jonathan D. Gitlin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 19},
  pages={10812-7}
}
Aceruloplasminemia is an autosomal recessive disorder of iron metabolism. Affected individuals evidence iron accumulation in tissue parenchyma in association with absent serum ceruloplasmin. Genetic studies of such patients reveal inherited mutations in the ceruloplasmin gene. To elucidate the role of ceruloplasmin in iron homeostasis, we created an animal model of aceruloplasminemia by disrupting the murine ceruloplasmin (Cp) gene. Although normal at birth, Cp(-/-) mice demonstrate progressive… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 166 extracted citations

References

Publications referenced by this paper.

Harris et al

  • X. Y. Zhou, S. Tomatsu, +9 authors 2492–2497. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 96
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…