Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo.

@article{Issa2006TargetedGD,
  title={Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo.},
  author={Mohamed M Issa and Magnus K{\"o}ping-H{\"o}gg{\aa}rd and Kristoffer T\ommeraas and Kjell Morten V{\aa}rum and Bj\orn Christensen and Sabina P. Strand and Per Artursson},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={115 1},
  pages={103-12}
}
The aim of this study was to improve the gene delivery efficacy of chitosan oligomer polyplexes by introducing a trisaccharide branch that targets cell-surface lectins. For this purpose, chitosan oligomers were substituted by a trisaccharide with the N-acetylglucosamine residue at the free end, and the ability of the trisaccharide-substituted chitosan oligomers (TCO) polyplexes to transfect various cell lines in vitro and lung tissue after in vivo administration to mice was investigated. Live… CONTINUE READING