Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence.

@article{Kleczka2007TargetedGD,
  title={Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence.},
  author={Barbara Kleczka and Anne-Christin Lamerz and Ger van Zandbergen and Alexander Wenzel and Rita Gerardy-Schahn and Martin Wiese and Françoise H Routier},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 14},
  pages={
          10498-505
        }
}
Considering the high incidence of galactofuranose (Gal(f)) in pathogens and its absence from higher eukaryotes, the enzymes involved in the biosynthesis of this unusual monosaccharide appear as attractive drug targets. However, although the importance of Gal(f) in bacterial survival or pathogenesis is established, its role in eukaryotic pathogens is still undefined. Recently, we reported the identification and characterization of the first eukaryotic UDP-galactopyranose mutases. This enzyme… CONTINUE READING
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