Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.

@article{Janssen2002TargetedEO,
  title={Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.},
  author={Klaus-Peter Janssen and Fatima el-Marjou and Daniel R. Pinto and Xavier Sastre and Dany Rouillard and Coralie Fouquet and Thierry Soussi and Daniel Louvard and Sylvie Robine},
  journal={Gastroenterology},
  year={2002},
  volume={123 2},
  pages={492-504}
}
BACKGROUND & AIMS Ras oncoproteins are mutated in about 50% of human colorectal cancers, but their precise role in tumor initiation or progression is still unclear. METHODS This study presents transgenic mice that express K-ras(V12G), the most frequent oncogenic mutation in human tumors, under control of the murine villin promoter in epithelial cells of the large and small intestine. RESULTS More than 80% of the transgenic animals displayed single or multiple intestinal lesions, ranging… CONTINUE READING

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