Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.

@article{Drago1998TargetedEO,
  title={Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.},
  author={John L Drago and P Padungchaichot and John Y L Wong and Andrew J Lawrence and J. F. A. McManus and Sony Heru Sumarsono and Anthony L. Natoli and Merja Lakso and Nigel G. Wreford and Heiner Westphal and Ismail Kola and David Isaac Finkelstein},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 23},
  pages={9845-57}
}
Idiopathic Parkinson's disease involves the loss of midbrain dopaminergic neurons, resulting in the presynaptic breakdown of dopaminergic transmission in the striatum. Huntington's disease and some neurodegenerative diseases with Parkinsonian features have postsynaptic defects caused by striatal cell death. Mice were generated in which an attenuated form of the diphtheria toxin gene (tox-176) was expressed exclusively in D1 dopamine receptor (D1R)-positive cells with the aim of determining the… CONTINUE READING