Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population.

@article{Tsai2005TargetedEO,
  title={Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population.},
  author={Pei-San Tsai and Suzanne M. Moenter and Hector Postigo and Mohammed eL Majdoubi and T R Pak and John C. Gill and Sreenivasan Paruthiyil and Sabine Werner and Richard I. Weiner},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 1},
  pages={225-36}
}
Increasing evidence suggests that fibroblast growth factors (FGFs) are neurotrophic in GnRH neurons. However, the extent to which FGFs are involved in establishing a functional GnRH system in the whole organism has not been investigated. In this study, transgenic mice with the expression of a dominant-negative FGF receptor mutant (FGFRm) targeted to GnRH neurons were generated to examine the consequence of disrupted FGF signaling on the formation of the GnRH system. To first test the… CONTINUE READING

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Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
Although these mice were initially fertile , they displayed several reproductive defects , including delayed puberty , reduced litter size , and early reproductive senescence .
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