Targeted estrogen delivery reverses the metabolic syndrome

@article{Finan2012TargetedED,
  title={Targeted estrogen delivery reverses the metabolic syndrome},
  author={Brian Finan and Bin S. Yang and Nickki L Ottaway and Kerstin Stemmer and T. D. M{\"u}ller and Chunwang Yi and Kirk M Habegger and Sonja C Schriever and Cristina Garc{\'i}a-C{\'a}ceres and Dhiraj G. Kabra and Jazzminn L. Hembree and Jenna Marie Holland and Christine Raver and Randy J Seeley and Wolfgang Hans and Martin Irmler and Johannes Beckers and Martin Hrab{\'e} de Angelis and Joseph P. Tiano and Franck Mauvais-Jarvis and Diego P{\'e}rez-Tilve and Paul Pfluger and Lianshan Zhang and Vasily M Gelfanov and Richard D DiMarchi and Matthias H Tsch{\"o}p},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1847-1856}
}
We report the development of a new combinatorial approach that allows for peptide-mediated selective tissue targeting of nuclear hormone pharmacology while eliminating adverse effects in other tissues. Specifically, we report the development of a glucagon-like peptide-1 (GLP-1)-estrogen conjugate that has superior sex-independent efficacy over either of the individual hormones alone to correct obesity, hyperglycemia and dyslipidemia in mice. The therapeutic benefits are driven by pleiotropic… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 87 CITATIONS

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 13 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Similar Papers

Loading similar papers…