Targeted drug conjugates: principles and progress.

  title={Targeted drug conjugates: principles and progress.},
  author={Martin C Garnett},
  journal={Advanced drug delivery reviews},
  volume={53 2},
Reports of targeting drugs using antibodies have appeared in the literature since 1958, but exciting clinical results in this field have only been reported in the last few years. Progress in this field has occurred largely through an understanding how drug-immunoconjugates work. The objective of this review is to draw together the fundamental principles on which this field of work is based, to examine the evidence supporting those principles, and the effectiveness and selectivity of targeted… CONTINUE READING