Targeted disruption of the testicular SPAG5/deepest protein does not affect spermatogenesis or fertility.

@article{Xue2002TargetedDO,
  title={Targeted disruption of the testicular SPAG5/deepest protein does not affect spermatogenesis or fertility.},
  author={Jiaping Xue and Heide A Tarnasky and D. E. Rancourt and Frans A van der Hoorn},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 7},
  pages={
          1993-7
        }
}
In an effort to define the molecular basis for morphogenesis of major sperm tail structures, including outer dense fibers, we recently cloned the Spag5 gene by virtue of its strong and specific leucine-zipper-mediated interaction with Odf1, the 27-kDa major outer dense fiber protein. Spag5 is expressed during meiosis and in round spermatids and is similar, if not identical, to Deepest, a putative spindle pole protein. Here we report the disruption of the Spag5 gene by homologous recombination… CONTINUE READING
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