Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.

@article{Saeki2002TargetedDO,
  title={Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.},
  author={Keiichi Saeki and Min Zhu and Atsutaka Kubosaki and Jingping Xie and M. S. Lan and Abner Louis Notkins},
  journal={Diabetes},
  year={2002},
  volume={51 6},
  pages={1842-50}
}
IA-2 is a major autoantigen in type 1 diabetes. Autoantibodies to IA-2 appear years before the development of clinical disease and are being widely used as predictive markers to identify individuals at risk for developing type 1 diabetes. IA-2 is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase family and is an integral component of secretory granules in neuroendocrine cells. To study its function, we generated IA-2-deficient mice. Northern and Western blot… CONTINUE READING