Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells.

Abstract

The evidence that androgen blockade-resistant prostate cancer, termed castration resistant, remains androgen receptor (AR) dependent is compelling. AR is re-activated through multiple mechanisms including expression of constitutively active splice variants that lack hormone binding domains (HBDs). This highlights the need to develop therapies that target… (More)
DOI: 10.1016/j.biocel.2012.12.012

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@article{Nakka2013TargetedDO, title={Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells.}, author={Manjula Nakka and Irina Agoulnik and Nancy L. Weigel}, journal={The international journal of biochemistry & cell biology}, year={2013}, volume={45 4}, pages={763-72} }