Targeted disruption of the murine zyxin gene.

  title={Targeted disruption of the murine zyxin gene.},
  author={Laura M. Hoffman and David A. Nix and Beverly Benson and Ray Boot-Hanford and Erika Gustafsson and Colin Jamora and A. Sheila Menzies and Keow Lin Goh and Christopher C. Jensen and Frank B. Gertler and Elaine Fuchs and Reinhard F{\"a}ssler and Mary C Beckerle},
  journal={Molecular and cellular biology},
  volume={23 1},
Zyxin is an evolutionarily conserved protein that is concentrated at sites of cell adhesion, where it associates with members of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family of cytoskeletal regulators and is postulated to play a role in cytoskeletal dynamics and signaling. Zyxin transcripts are detected throughout murine embryonic development, and the protein is widely expressed in adults. Here we used a reverse genetic approach to examine the consequences of loss of… CONTINUE READING