Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.

  title={Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.},
  author={Yingzi Yang and Ye Kuang and Rocio Montes de Oca and Thomas S Hays and Lisa Moreau and Naifang Lu and Brian Seed and Alan D' Andrea},
  volume={98 12},
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation. Six FA genes (corresponding to subtypes A, C, D2, E, F, and G) have been cloned, and the encoded FA proteins interact in a common cellular pathway. To further understand the in vivo role of one of these human genes (FANCG), we generated a targeted disruption of murine Fancg and bred mice homozygous for the targeted allele. Similar to the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Association of complementation group and mutation type with clinical outcome in fanconi anemia . European Fanconi Anemia Research Group

  • B Hogan, R Beddington, F Costantini, E Lacy
  • Blood
  • 2000

Isolation of a cDNA representing the Fanconi anemia complementation group E gene

  • JP de Winter, F Leveille, CGM van Berkel
  • Am J Hum Genet
  • 2000

Pheno typic correction of Fanconi anemia group C knockout mice

  • KA Gush, Fu K-L, M Grompe, CE Walsh
  • Blood
  • 2000

Similar Papers

Loading similar papers…