Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility

  title={Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility},
  author={Yunqiang Liu and Da-chang Tao and Yongjie Lu and Yuan Yang and Yongxin Ma and Si-zhong Zhang},
  journal={Genetics and Molecular Biology},
  pages={708 - 715}
The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa. To investigate the role of Znf230 in spermatogenesis, we generated Znf230-deficient mice by disrupting Znf230 exon-5 and exon-6 using homologous recombination. The homozygous Znf230-knockout (KO) mice did not exhibit Znf230 mRNA expression and Znf230 protein production. Znf230 KO mice exhibited no obvious impairment in… 
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